Set a few dps near your sets and bait with persimmons, hopefully catch the skunks before they make it to your dirt holes/flat sets. Worst case like they said, catching a skunk in your set will actually help as an attractant.
I've used dps for years using a persimmon paste bait and have never caught anything but coons...my target and reason for the DP s
I'd set up some skunk sets afore hand and thin them out...or raise pan pressure like others have said ^^