Newhouse 114 - Hopefully you'll get very, very few like that. Most I can cautiously approach to within 3-4 feet, then hit them with a direct stream of chloroform. A few are pacing as i drive up and get more agitated as i approach unti they're displaying and pounding their feet at 10 feet. The sprayer I use (Tough Guy trigger sprayer from Grainger Industrial Supply,
www.grainger.com) will reach out 8-10 feet at most, but it's mostly a cloud of droplets then. Still works, just need more of it. A few really agitated ones I had to move in on really, really slowly, one step at a time, took 15-20 minutes or more to get in range, but I got them. The danger sign is them flaring their tail and pounding their feet and lunging towards you. Just wait until they stop doing that and resume their pacing, then cautiously move one more step closer. Wait a few seconds and if no displaying take another step. Stop the second they start displaying again, move in another step when they go back to just pacing. For me at least, it's unusual to have to do this, maybe 1 in 50. Of course if that flared pink rectum is aimed at you, don't try anything!
I had one really agitated skunk spray as soon as I hit him from 8-10 feet, and had a couple I had to spray repeatedly and took almost an hour to numb down. But those are the exceptions. I have yet to have one that was completely unapproachable, eventually.
Chloroform isn't perfect, but 95% is good enough for me. Nothing is guaranteed perfect with skunks!