When I ran long lines I usually had about 150 traps out - maybe 175. I worked until 4:30 then checked traps and got home by midnight most nights. I sold all my coon on the carcass and finished all the rest. My trap line was about 160 miles long. I had to drive about 20 miles on both ends of it.
I had a good system which is what you need or it will cost you a lot and waste time. I moved traps on the weekend and made sure all of the sets were baited Sunday and again Wednesday. I did not carry bait every day but carried lure in a squeeze bottle every night. If I carried bait every day I would get it all over me and the truck... I ran lots of pockets on drowners with some bind sets thrown in where they made sense. Every stop would get at least two sets and some of the best would get a dozen. I usually put 4 pockets below a good pool if the sign was there. All four had drowners and I would usually use only a stake by the bank then run the cables out to deep water and wire them all together. When things worked out sometimes I would have 4 coon or a mink and a rat- you never know, maybe a beaver or coyote too. You have to catch all you can of all species to make any money. The coon pay the gas and the other fur typically pays your wages so you don't want to pass up anything. We have a rule that says we have to check each trap once a day and remove any animal. That's a lot of driving around every day. Here it works well to run traps for two weeks then pull out and go back 3/4 weeks later and do it again in the same sets if the weather isn't too bad. Keep good records and have a notebook full of contacts and plat books of your area. Don't do it on a smart phone cause you'll drop it in a creek and lose it all. I couldn't run traps all season this way. It wears you out. You will need a couple freezers - maybe more- to hold all the fur till you can take care of it. I could never get more than 50 good stops.
Like some of the guys above are saying - always gang set. I had a spot I put in 12 pocket sets and ran them for ten days and got 80 coons - all from just that one spot. Good bait and lure, traps, good habitat, and work your tail off! Oh yeah and the secret to trapping is that there isn't one! Ha!