E3 is best.

E3.
There is no " off side shouldr" exit shot here that is favorable!

Top line of F2. Your shot would go behind the front ham and out. That der would live.

Standing on top of the hay with its feet on the ground ? I am sure there has been lots shot at an angle to the side just not something I have done myself.

In order to have a chance at hitting that deer in the head with a bow, you may well be just as likely to connect if to hold at A5. The deer is looking at you. When he hears that string let go, he will likely whip his head all the way around by the time the arrow gets there. Do all deer lurch at the sound of the string? No. Maybe 5-10% don't. 90-95% will.

Similar logic applies to hitting that deer in the heart. You must be able to predict where that deer's heart will be by the time the arrow gets there.
If you watch enough slo-mo videos of bow killed deer, You will see how low they hold on the deer in order for it to duck into the arrow. A lot of them are holding on chest brisket hair, then the deer ducks so that the arrow hits the sweet spot.

X marks the spot- Here's what E 2.5 looks like

Wolfie,

Make life easy on yourself.

Forget numbers on a chart.

On angle shot always aim for the off side shoulder. Dead critter every time.

I'd aim at F2 because the deer is gonna drop at 20-30 yards.