OK Mando are you going to give us the context of the question?
places 223/5.56 over 308/7.62x51
if it is your wife's bed room gun , a home owners job in a home invasion is cell phone and gun either stay in the master bedroom or get to the kids room and close the door , take defensive position and initiate 911 call on speaker holding gun on door.
pros of the 223/5.56 more rounds in mag ,less recoil , marginally less blast , faster follow up using the correct round less over penetration
this is where you could also make a good argument for 300blk / 7.62x35 because it has all the same attributes but can be a little less blasty yet from the 16 inch barrel because it uses a faster burning powder that is much more burned up by 16 inches.
really any indoor use or close range use the 223/5.56 or 300bkl/7.62x35 are better tool than 308 unless there are extenuating circumstances.
is rounds in mag a huge factor? if one gun is 20 and the other 30 , 20 was probably enough rounds.
if you have ever let a round from either of these go indoors , wow that is loud , and the muzzle blast is a lot
it wouldn't hurt to have hearing protection , if you could hang a set of electronics next to the gun , grab gun , toss sling over body , put a round in battery , toss on hearing protection turn on , grab phone move to position, that is just a lot of steps , but could have them hanging there adjusted for size and if you don't get to them , you don't get to them.
electronics because you can hear the creak of the floor , the juggle of a door knob but also the cut out on the shot.
in an ideal world everyone would have a suppressor but , it isn't an ideal world and you can have 3-4 good pair of electronics or the cost of the restrictive tax on a suppressor.